ea0021p127 | Cytokines and growth factors | SFEBES2009
Sharples Adam
, Al-Shanti Nasser
, Stewart Claire
Inflamed ageing is associated with reduced muscle mass and increased susceptibility to TNF-induced muscle protein degradation. We therefore aimed to elucidate mechanisms supporting reduced hypertrophy and increased atrophy of skeletal myoblasts. C2 myoblasts display diminished differentiation and increased susceptibility to TNF-α-induced apoptosis versus daughter C2C12 cells, providing us with relevant models. C2 and C2</su...